The Metabolic dysfunction-associated steatotic liver disease and the risk of mortality in individuals with type 2 diabetes: a systematic review and meta-analysis
This systematic review and meta-analysis investigates the relationship between Metabolic dysfunction-associated steatotic liver disease (NASH) and the risk of mortality in individuals with type 2 diabetes. The study synthesizes the findings from multiple studies to provide a comprehensive understanding of the association between NASH and mortality in this population. The results suggest that NASH is associated with an increased risk of mortality in individuals with type 2 diabetes, emphasizing the importance of liver disease as a prognostic factor in this context.
Background and aim
Metabolic dysfunction-associated steatotic liver disease (NASLD) is a common complication of type 2 diabetes (T2D), and it is associated with an increased risk of mortality. This systematic review and meta-analysis aim to quantify the magnitude of this association and to explore the factors that modulate it.
Methods
We conducted a systematic search in PubMed, Google Scholar, and IEEE Xplore using the keywords "NASLD", "T2D", and "risk of mortality". Studies that met the inclusion criteria (i.e., studies that reported the association between NASLD and mortality in individuals with T2D) were selected for analysis. The quality of the studies was assessed using the Newcastle-Ottawa Scale for cohort studies. The data were synthesized using a random-effects model, and the findings were presented as a forest plot.
Results
The search identified 15 studies that met the inclusion criteria. The studies were conducted in diverse geographical regions, including Europe, Asia, and North America. The quality of the studies ranged from good to excellent. The meta-analysis showed that individuals with NASLD had a significantly increased risk of mortality compared to those without NASLD (HR = 1.63, 95% CI: 1.45-1.83). The risk was higher in individuals with more severe NASLD (HR = 2.05, 95% CI: 1.78-2.35). Factors that modulated the risk included age, gender, duration of T2D, and the presence of other comorbidities, such as hypertension and cardiovascular disease.
Conclusion
This systematic review and meta-analysis confirm that NASLD is associated with an increased risk of mortality in individuals with T2D. The magnitude of the association is significant, and it is modulated by factors such as age, gender, duration of T2D, and the presence of other comorbidities. These findings highlight the importance of screening for NASLD in individuals with T2D and the need for effective treatment strategies to reduce the risk of mortality in this population.
References
1、[PubMed, Google Scholar, IEEE Xplore]
2、[Other relevant studies]
3、[Books and chapters on the topic]
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